GBDR1 rabbit pAb - 50 μL

Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 STI1 domain. similarity: Contains 1 ubiquitin-like domain. similarity: Contains 2 UBA domains. subunit: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain. tissue specificity: Ubiquitous.