PAOX rabbit pAb - 50 μL

Catalytic activity: N (1), N (12)-diacetylspermine + O (2) + H (2)O = N (1)-acetylspermidine + 3-acetamidobutanal + H (2)O (2). Catalytic activity: N (1)-acetylspermidine + O (2) + H (2)O = putrescine + 3-acetamidopropanal + H (2)O (2). Catalytic activity: N (1)-acetylspermine + O (2) + H (2)O = spermidine + 3-acetamidopropanal + H (2)O (2). Cofactor: Binds 1 FAD per subunit. function: Flavoenzyme which catalyzes the oxidation of N (1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N (1)-acetylspermidine to putrescine. Substrate specificity: N (1)-acetylspermine = N (1)-acetylspermidine > N (1), N (12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. induction: By polyamine analogs. miscellaneous: Oxidizes N (1)-acetylated polyamines on the exo-side of their N (4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N (4)-nitrogen. pathway: Amine and polyamine metabolism; spermine metabolism. similarity: Belongs to the flavin monoamine oxidase family. subunit: Monomer. tissue specificity: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.